.article-details p, .article-details li, .article-details ul, .article-details ol, .article-details h2, .article-details h3, .article-details h4 {
  line-height: 1.5;
}
.article-details{
  font-family: Calibri,"Times New Roman","Times",serif;
}
.heading{
  font-size: 18px;
}
.heading .nature{
  float: left;
  color: #5b616b;
  display: inline-block;
  line-height: 1.5;
}
.heading .nature a{
  font-size: 18px;
  cursor: pointer;
}

.nature .journal{
  float: left;
  font-weight: 600;
  margin-right: 10px;
}
.nature .journal a{
  color: #279ef2;
}
.heading .heading-title{
  text-align: left;
  font-size: 1.8rem;
  line-height: 1.4;
  margin: 1rem 0 1.2rem;
  word-wrap: break-word;
  font-weight: 300;
}
.inline-authors a{
  font-size: 18px;
  white-space:nowrap;
  color: #205493;
}
.heading a:hover {
  color: #205493;
}
.heading .inline-authors {
  margin-bottom: 1.2rem;
}
.heading .short-citation {
  line-height: 1.5;
  color: #5b616b;
}
.authors-list {
  display: inline;
  line-height: 1.5;
}
.authors-list .authors-list-item  {
  display: inline-block;
  float: left;
  padding-right: 4px;
}
.authors-list .authors-list-item .equal-contrib-container {
  font-size: 75%;
}
.article-page .article-details .authors-list .authors-list-item .affiliation-link, .article-details .authors-list .authors-list-item .equal-contrib {
  font-size: inherit;
  display: inline-block;
  line-height: 1;
  padding: 0.1rem 0.3rem;
  border-radius: 2px;
  background-color: #f1f1f1;
  color: #323a45;
  transition: color 0.3s;
}
.authors-list .authors-list-item .equal-contrib {
  font-size: inherit;
  display: inline-block;
  line-height: 1;
  padding: 0.1rem 0.3rem;
  border-radius: 2px;
  background-color: #f1f1f1;
  color: #323a45;
  transition: color 0.3s;
}
.article-details .identifiers {
  padding: 0;
  margin: 0;
  display: block;
  list-style: none;
  margin-top: 10px;
}
.article-details .identifiers .current-id {
  font-weight: normal;
  color: #212121;
}
.identifiers .pubmed {
  float: left;
  padding-right: 10px;
}
.abstract-title{
  font-size: 1.8rem;
  line-height: 1.4;
  margin: 1rem 0 0.6rem;
  word-wrap: break-word;
  font-weight: 300;
}

.references{
  font-size: 18px;
  line-height: 1.4;
  margin: 1rem 0 0.6rem;
  word-wrap: break-word;
  font-weight: 300;
}
.abstract{
  text-align: left;
}
.abstract p{
  text-align: justify;
}
.abstract span{
  padding: 0 0 0 20px;
}
.abstract h5{
  text-align: left;
}
.abstract img{
  margin-top: 4px;
}
.references-list {
  padding: 0;
  margin: 0;
  display: block;
  list-style: none;
  padding-left: 3rem;
  margin: 1.2rem 0;
}
.references .refs-list {
  word-break: break-word;
}
.references-list>li {
  list-style: decimal outside;
  padding-left: 1rem;
  word-wrap: break-word;
}
.skip-numbering {
  list-style-type: none;
  counter-increment: none;
}
ol {
  display: block;
  list-style-type: decimal;
  margin-block-start: 1em;
  margin-block-end: 1em;
  margin-inline-start: 0px;
  margin-inline-end: 0px;
  padding-inline-start: 40px;
}
li {
  display: list-item;
  text-align: -webkit-match-parent;
}
.affiliation{
  text-align: left;
  width: 100%;
  margin: 10px 0px;
}

.affiliation ul{
  list-style-type: none;
  float: left;
  cursor: pointer;
}

.affiliationDiv{
  text-align: justify;
  font-size: 12px;
}
.ico-up{
  margin-top: 5px;
  margin-left: 5px;
  float: left;
  width:0;
  height:0;
  border:5px solid transparent ;
  border-bottom-color:rgb(36, 163, 248);
  cursor: pointer;
}
.ico-down{
  float: left;
  cursor: pointer;
  margin-top: 10px;
  margin-left: 5px;
  width:0;
  height:0;
  border:5px solid transparent ;
  border-top-color:rgb(36, 163, 248);
}